ayahuasca

Ayahuasca
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This entry focuses on the Ayahuasca brew; for information on the vine of the same name, see Banisteriopsis caapi

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Ayahuasca (ayawaska pronounced [ajaˈwaska] in the Quechua language) is any of various psychoactive infusions or decoctions prepared from the Banisteriopsis spp. vine, usually mixed with the leaves of DMT-containing species of shrubs from the Psychotria genus. It was first described academically in the early 1950s by the late Harvard ethnobotanist Richard Evans Schultes who found it employed for divinatory and healing purposes by Amerindians of Amazonian Colombia.
Contents [hide]
1 Preparation
2 Names
3 Chemistry
4 Usage
4.1 Introduction to Europe and North America
4.2 "Ayahuasca tourism"
4.2.1 Initiation
5 Modern descriptions
5.1 Related phenomena
6 Plant constituents
6.1 Traditional
7 Legal status
8 International Research
9 See also
10 External links
10.1 Ayahuasca churches
10.2 Law
10.3 Native Centres in the Amazon
10.4 Other
11 Literature
11.1 Nonfiction
11.2 Fiction
12 Filmography
12.1 Documentaries
12.2 Fiction films
13 References
[edit]Preparation



Ayahuasca being prepared in the Napo region of Ecuador.


Freshly harvested caapi vine ready for preparation
Sections of B. caapi vine are macerated and boiled alone or with leaves from any of a number of other plants, including Psychotria viridis (chacruna) or Diplopterys cabrerana (also known as chaliponga). The resulting brew contains the powerful hallucinogenic alkaloid N,N-dimethyltryptamine (DMT), and MAO inhibiting harmala alkaloids, which are necessary to make the DMT orally active. Though B. caapi is a central ingredient in traditional ayahuasca brews, harmala-containing plants from other plant-medicine cultures, such as Syrian Rue, can be used instead of the vine to make an ayahuasca analogue, yet it isn't considered ayahuasca, as Caapi vine is considered the main plant in the brew.[citation needed]


Banisteriopsis caapi preparation


Beaten caapi ready for boiling


Caapi cooking over an open fire
Brews can also be made with no DMT-containing plants; Psychotria viridis being substituted by plants such as Justicia pectoralis, Brugmansia, or sacred tobacco, also known as Mapacho (Nicotiana rustica), or sometimes left out with no replacement. The potency of this brew varies radically from one batch to the next, both in strength[clarification needed] and psychoactive effect, based mainly on the skill of the shaman or brewer, as well as other admixtures sometimes added and the intent of the ceremony.[citation needed] Natural variations in plant alkaloid content and profiles also affect the final concentration of alkaloids in the brew, and the physical act of cooking may also serve to modify the alkaloid profile of harmala alkaloids.[1][2]
Individual polymorphisms in the cytochrome P450-2D6 enzyme affect the ability of individuals to metabolize harmine.[3] Some natural tolerance to habitual use of ayahuasca (roughly once weekly) may develop through upregulation of the serotonergic system.[4] A phase 1 pharmacokinetic study on Ayahuasca (as Hoasca) with 15 volunteers was conducted in 1993, during the Hoasca Project.[5] A review of the Hoasca Project has been published.[6]
[edit]Names

"cipó" (generic vine, liana), "caapi", "hoasca" or "daime" in Brazil
"yagé" or "yajé" (both pronounced [ʝaˈhe]) in Colombia; popularized in English by the beat generation writers William S. Burroughs and Allen Ginsberg in The Yage Letters.
"ayahuasca" or "ayawaska" ("Spirit vine" or "vine of the souls": in Quechua, aya means "vine" while huasca or waska means "spirit") in Ecuador, Bolivia and Peru, and to a lesser extent in Brazil. The spelling ayahuasca is the hispanicized version of the name; many Quechua or Aymara speakers would prefer the spelling ayawaska. The name is properly that of the plant B. caapi, one of the primary sources of beta-carbolines for the brew.
"natem" amongst the indigenous Shuar people of Peru.
"Grandmother"
[edit]Chemistry

Harmine compounds are of beta-carboline origin. The three most studied beta-carboline compounds found in the B. caapi vine are harmine, harmaline and tetrahydroharmine. Harmine and harmaline are selective and reversible inhibitors of MAO-A, while tetrahydroharmine is a weak serotonin uptake inhibitor. This inhibition of MAO-A allows DMT to diffuse unmetabolized past the membranes in the stomach and small intestine and eventually get through the blood-brain barrier to activate receptor sites in the brain. Without the MAOI of MAO-A, DMT would be metabolized in the digestive tract and would not have an effect when taken orally.
[edit]Usage



Urarina shaman, 1988
Ayahuasca is used largely as a religious sacrament. Those whose usage of ayahuasca is performed in non-traditional contexts often align themselves with the philosophies and cosmologies associated with ayahuasca shamanism, as practiced among indigenous peoples like the Urarina of Peruvian Amazonia. The religion Santo Daime uses it.
While non-native users know of the spiritual applications of ayahuasca, a less well-known traditional usage focuses on the medicinal properties of ayahuasca. Its purgative properties are highly important (many refer to it as la purga, "the purge"). The intense vomiting and occasional diarrhea it induces can clear the body of worms and other tropical parasites,[7] and harmala alkaloids themselves have been shown to be anthelmintic[8] Thus, this action is twofold; a direct action on the parasites by these harmala alkaloids (particularly harmine in ayahuasca) works to kill the parasites, and parasites are expelled through the increased intestinal motility that is caused by these alkaloids.
Dietary taboos are almost always associated with the use of Ayahuasca. In the rainforest, these tend towards the purification of one's self - abstaining from spicy and heavily-seasoned foods, excess fat, salt, caffeine, acidic foods (such as citrus) and sex before, after, or both before and after a ceremony. A diet low in foods containing tyramine has been recommended, as the speculative interaction of tyramine and MAOIs could lead to a hypertensive crisis. However, evidence indicates that harmala alkaloids act only on MAO-A, in a reversible way similar to moclobemide (an antidepressant that does not require dietary restrictions). Psychonautic experiments and the absence of dietary restrictions in the highly urban Brazilian ayahuasca church União do Vegetal also suggest that the risk is much lower than conceived, and probably non-existent.[9]
The name 'ayahuasca' specifically refers to a botanical decoctions that contains Banisteriopsis caapi. A synthetic version, known as pharmahuasca is a combination of an appropriate MAOI and typically DMT. In this usage, the DMT is generally considered the main psychoactive active ingredient, while the MAOI merely preserves the psychoactivity of orally ingested DMT, which would otherwise be destroyed in the gut before it could be absorbed in the body. Thus, ayahuasqueros and most others working with the brew maintain that the B. caapi vine is the defining ingredient, and that this beverage is not ayahuasca unless B. caapi is in the brew. The vine is considered to be the "spirit" of ayahuasca, the gatekeeper and guide to the otherworldly realms.
In some areas, it is even said that the chakruna or chaliponga admixtures are added only to make the brew taste sweeter. This is a strong indicator of the often wildly divergent intentions and cultural differences between the native ayahuasca-using cultures and psychedelics enthusiasts in other countries.
In modern Europe and North America, ayahuasca analogues are often prepared using non-traditional plants which contain the same alkaloids. For example, seeds of the Syrian rue plant are often used as a substitute for the ayahuasca vine, and the DMT-rich Mimosa hostilis is used in place of chakruna. Australia has several indigenous plants which are popular among modern ayahuasqueros there, such as various DMT-rich species of Acacia.


Ayahuasca cooking in the Napo region of Ecuador.
In modern Western culture, entheogen users sometimes base concoctions on Ayahuasca. When doing so, most often Rue or B. caapi is used with an alternative form of the DMT molecule, such as psilocin, or a non-DMT based hallucinogen such as mescaline. Nicknames such as Psilohuasca, Mush-rue-asca, or 'Shroom-a-huasca, for mushroom based mixtures, or Pedrohuasca (from the San Pedro Cactus, which contains mescaline) are often given to such brews. Such nicknames are considered by many to be inappropriate and culturally insensitive. Further, the psychedelic experimentalist trappings of such concoctions bear little resemblance to the medicinal use of Ayahuasca in its original cultural context, where ayahuasca is usually ingested only by experienced entheogen users who are more familiar with the chemicals and plants being used, as the uninformed combination of various neurochemicals can be dangerous.
It seems unlikely that Ayahuasca could ever emerge as a "street-drug", given the difficulty of making the brew and the intense experience it provides. Most Western users employ it almost exclusively for spiritual purposes, in line with both traditional, animist usage and organized churches such as the União do Vegetal (or UDV). With the exception of UDV, a diet is almost always followed before use, including a day of fasting. In traditional settings, the "dieta" is followed to spiritually cleanse the body before and after the experience.
[edit]Introduction to Europe and North America
Ayahuasca is mentioned in the writings of some of the earliest missionaries to South America, but it only became commonly known in Europe and North America much later.[specify] The early missionary reports generally claim it as demonic, and great efforts were made by the Roman Catholic Church to stamp it out. When originally researched in the 20th century, the active chemical constituent of B. caapi was called telepathine, but it was found to be identical to a chemical already isolated from Peganum harmala and was given the name harmaline. The original botanical description done was the Harvard ethnobotanist Richard Evans Schultes. Having read Schultes's paper, Beat writer William Burroughs sought yagé (still referred to as "telepathine") in the early 1950s while traveling through South America in the hopes that it could relieve or cure opiate addiction (see The Yage Letters). Ayahuasca became more widely known when the McKenna brothers published their experience in the Amazon in True Hallucinations. Dennis later studied the pharmacology, botany, and chemistry of ayahuasca and oo-koo-he, which became the subject of his master's thesis.
In Brazil, a number of modern religious movements based on the use of ayahuasca have emerged, the most famous of them being Santo Daime and the União do Vegetal (or UDV), usually in an animistic context that may be shamanistic or, more often (as with Santo Daime and the UDV), integrated with Christianity. Both Santo Daime and União do Vegetal now have members and churches throughout the world. Similarly, the US and Europe have started to see new religious groups develop in relation to increased ayahuasca use. PaDeva, an American Wiccan group, has become the first incorporated legal church which holds the use of ayahuasca central to their beliefs. Some Westerners have teamed up with shamans in the Amazon rainforest regions, forming Ayahuasca healing retreats that claim to be able to cure mental and physical illness and allow communication with the spirit world. Anecdotal reports and scientific studies affirm that ritualized use of ayahuasca may improve mental and physical health.[10]
Several notable celebrities have publicly discussed their use of ayahuasca, including Sting (detailed in his 2003 memoir Broken Music), Tori Amos, and Paul Simon (who wrote the song "Spirit Voices" about his experience with the brew in the Amazon).
Recent years have seen notable media attention to the position of the UDV church in the United States. After having their importation and use of Hoasca tea challenged by the U.S. Department of Justice, and then having the issue settled in their favor by the U.S. Supreme Court, the church gained some notoriety. This mirrors in some ways the experiences of UDV and Santo Daime churches in Europe, where legal authorities have taken interest in their activities in France, Germany, Holland and Spain.
Holland was an early Western context for the spread of ayahuasca use. Supporting a large Brazilian population, Santo Daime members in particular made efforts to spread the philosophy of ritualized ayahuasca use. In the mid-to-late 1990s one group, the Amsterdam-based Friends of the Forest, was formed by Santo Daime members to introduce ayahuasca to Europeans and others with "allergies to Christianity." They did this by introducing "New Age" rituals incorporating basic ritual structure, celebrating with songs in the Daime tradition (Portuguese waltzes), English language songs, ambient music and mantras and kirtan. They existed at least until the Dutch authorities raided a Santo Daime ritual in progress, and other ayahuasca-oriented groups sensed that an obvious public profile was not in their best interest. Amsterdam is also among the few cities in Europe where one can find, in addition to cannabis, psilocybin mushrooms and peyote, ayahuasca vine, chacruna leaves, and plants for ayahuasca analogues in the tradition of Jonathan Ott's so-called "ayahuasca borealis."
[edit]"Ayahuasca tourism"
"Ayahuasca tourist" refers to a tourist wanting a taste of an exotic ritual or who partakes in modified services geared specifically towards non-indigenous persons. Some seek to clear emotional blocks and gain a sense of peace. Other participants include explorers of consciousness, writers, medical doctors, journalists, anthropologists and ethnobotanists. Ayahuasca tourism is greatest in Peru, and attracts visitors from all over the world, especially from Europe, USA, Australia, and South Africa, but also from other Latin American countries like Argentina, Chile, Colombia and Mexico.
[edit]Initiation
Usually a visitor who wishes to become a "dietero" or "dietera", that is, a male or female apprentice-shaman learning the way of the teacher plants, undergoes a rigorous initiation. This can involve spending up to a year or more in the jungle. This initiation challenges and trains the initiate through extreme circumstances involving a special diet and numerous different plant medicines to complement the Ayahuasca, the lack of western food and conveniences, the harsh environmental conditions of heavy rains, storms, intense heat, insects, and poisonous animals. The initiate is also tested for their unwavering commitment to Ayahuasca and the shaman who oversees the training.
[edit]Modern descriptions

Wade Davis (author of The Serpent and The Rainbow [non-fiction][11][12]) describes the traditional mixture as tough in his book One River: "The smell and acrid taste was that of the entire jungle ground up and mixed with bile." [p.194]
Writer Kira Salak describes her personal experiences with ayahuasca in the March 2006 issue of National Geographic Adventure magazine[13][14] The article includes a candid description of how ayahuasca cured her depression, as well as provides detailed information about the brew. Here is an excerpt from the article about Dr. Charles Grob's landmark findings[15]:
The taking of ayahuasca has been associated with a long list of documented cures: the disappearance of everything from metastasized colorectal cancer to cocaine addiction, even after just a ceremony or two. It has been medically proven to be nonaddictive and safe to ingest. Yet Western scientists have all but ignored it for decades, reluctant to risk their careers by researching a substance containing the outlawed DMT. Only in the past decade, and then only by a handful of researchers, has ayahuasca begun to be studied. At the vanguard of this research is Charles Grob, M.D., a professor of psychiatry and pediatrics at UCLA’s School of Medicine.
In 1993 Dr. Grob directed the Hoasca Project, the first in-depth study of the physical and psychological effects of ayahuasca on humans. He and his team went to Brazil, where the plant mixture can be taken legally, to study members of a church, the União do Vegetal (UDV), who use ayahuasca as a sacrament, and compared them to a control group that had never ingested the substance. The studies found that all the ayahuasca-using UDV members had experienced remission without recurrence of their addictions, depression, or anxiety disorders. Unlike most common anti-depressants, which Grob says can create such high levels of serotonin that cells may actually compensate by losing many of their serotonin receptors, the Hoasca Project showed that ayahuasca strongly enhances the body’s ability to absorb the serotonin that’s naturally there [4]. 'Ayahuasca is perhaps a far more sophisticated and effective way to treat depression than SSRIs [antidepressant drugs],' Grob concludes, adding that the use of SSRIs is 'a rather crude way' of doing it. And ayahuasca, he insists, has great potential as a long-term solution in maintaining abstinence.
Chilean novelist Isabel Allende told The Sunday Telegraph in London that she once took the drug in an attempt to "punch through" writer's block[16]. The paper wrote:
But after forcing down the foul-tasting brew, she was catapulted to a place so dark her husband feared he had 'lost his wife to the world of spirits'. Her life flashed before her as the hallucinogen took hold. She faced demons, saw herself as a terrified four-year-old and curled up on the floor, shivering, retching and muttering for two days.

'I think I went through an experience of death at a certain point, when I was no longer a body or a soul or a spirit or anything,' Allende says matter-of-factly. 'There was just a total, absolute void that you cannot even describe because you are not. And I think that's death.'

Nevertheless, the process proved transformative. Allende emerged aching but lucid and was able to complete [a trilogy she was writing], now being adapted for film by the co-producers of The Chronicles of Narnia.
[edit]Related phenomena
There have been reports that a phenomenon similar to folie à deux had been induced most recently by anthropologists in the South American rainforest by consuming ayahuasca[17] and by military experiments for chemical warfare in the late 60's using the incapacitating agent BZ. In both incidents there were very rare claims of shared visual hallucinations.
[edit]Plant constituents

[edit]Traditional
Traditional Ayahuasca brews are always made with Banisteriopsis caapi as a MAOI, although DMT sources and other admixtures vary from region to region. There are several varieties of caapi, often known as different "colors", with varying effects, potencies, and uses.
DMT admixtures:
Psychotria viridis (Chacruna) - leaves
Diplopterys cabrerana (Chaliponga, Banisteriopsis rusbyana) - leaves
Psychotria carthagenensis (Amyruca) - leaves
Other common admixtures:
Justicia pectoralis
Brugmansia (Toé)
Nicotiana rustica (Mapacho, variety of tobacco)
Ilex guayusa, a relative of yerba mate
MAOI:
Harmal (Peganum harmala, Syrian Rue) - seeds
Passion flower
synthetic MAOIs
DMT admixture sources:
Acacia maidenii (Maiden's Wattle), Acacia phlebophylla, and other Acacias, most commonly employed in Australia - bark
Anadenanthera peregrina, A. colubrina, A. excelsa, A. macrocarpa
Mimosa hostilis (Jurema) - root bark - not traditionally employed with ayahuasca by any existing cultures, though likely it was in the past. Popular in Europe and North Americ